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We were unable to process your request. Please try again later. If you continue to have this issue please contact customerservice@slackinc.com. Back to Healio Key takeaways: Parenteral nutrition complications, especially infections and pain, remain a major burden in short bowel syndrome. Surveyed clinicians favored reduced time on reduced time on support over reduced volume. CHICAGO \u2014 For patients with short bowel syndrome, reduced time on parenteral support may mitigate burdens such as central line complications, fatigue and decreased quality of life, according to a survey of health care professionals. Results, presented at Digestive Disease Week, indicated that limiting the days per week and hours per day that patients spend receiving total parenteral nutrition (TPN) may benefit those with short bowel syndrome (SBS) reliant on this support.
\u201cReducing the risks associated with parenteral support \u2014 especially central venous access complications \u2014 should be a primary focus in SBS management,\u201d lead author Syed-Mohammed R. Jafri, MD, a gastroenterologist and transplant hepatologist at Henry Ford Health, told Healio. \u201cWhile maintaining adequate nutrition remains essential, clinicians clearly prioritize interventions that decrease hospitalizations, improve safety and reduce treatment burden. \u201cEven modest reductions in TPN use are considered meaningful and achievable clinical goals,\u201d he continued. Jafri and colleagues conducted a noninterventional, cross-sectional online survey of health care professionals to evaluate perceptions of TPN-related complications, clinical burden and outcome priorities for new therapies. Researchers identified 336 health care professionals \u2014 213 in Europe and 123 in the U.S. \u2014 who were actively managing at least one patient with SBS with a minimum 2 years of experience treating the condition. More than half of respondents were men (60.1%) and most were aged 40 to 59 years (69%). Among those surveyed, 42% were physicians, 23% were pharmacists and 18% were dietitians. Nearly half (45.2%) primarily practiced gastroenterology, 23.5% focused on clinical nutrition or nutritional support, and 17.3% specialized in internal medicine. According to results, common complications experienced by patients on TPN include central line infections (59.8%), fatigue (47.9%), central line pain (43.2%), stomach pain (40.5%), edema (37.5%) and thrombosis (29.5%) Central line infections (49.7%) and central line pain (44%) were identified as the most distressing complications for patients. Respondents cited concerns with central venous catheters (48.2%), reduction in quality of life (34.8%) and hepatotoxicity (32.4%) as key limitations of TPN. Top therapeutic priorities were reducing TPN days per week (46.4%) and hours per day (30.1%). Fewer respondents advocated for reducing TPN volume (11.3%). \u201cReducing the number of days on TPN directly decreases exposure to central venous catheters, thereby lowering the risk of infections, thrombosis and other complications,\u201d Jafri said. \u201cShorter infusion times may also reduce metabolic strain and improve patient adherence and overall management feasibility.\u201d Limiting TPN time could also ease the burden on caregivers, he added. The health care professionals also felt that reduced TPN dependence may improve quality of life (60.1%), result in fewer line infections (56%) and lower thrombosis risk (53.6%). \u201cLess dependence on infusions could translate to decreased hospitalization rates and reduced health care utilization, which were key priorities for clinicians in the survey,\u201d Jafri said. \u201cOver time, this shift could move the management of SBS from a high-risk, resource-intensive model toward a more stable and sustainable approach.\u201d For more information: Syed-Mohammed R. Jafri, MD, can be reached at gastroenterology@healio.com. Published by: Sources\/Disclosures Source: Jafri SR, et al. Burden of total parenteral nutrition for patients with short bowel syndrome dependent on parenteral support: Healthcare professional perspectives on risks, limitations and treatment priorities. Presented at: Digestive Disease Week; May 2-5, 2026; Chicago.
Disclosures:
Jafri reports no relevant financial disclosures. Please see the study for all other authors\u2019 relevant financial disclosures.
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