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We were unable to process your request. Please try again later. If you continue to have this issue please contact customerservice@slackinc.com. Back to Healio Key takeaways: Drinking at least one sugar-sweetened beverage daily was linked to 2.5 times the risk for developing gastric cancer. Researchers found no link between artificially sweetened beverages and gastric cancer. A prospective study of more than 110,000 individuals found consumption of at least one 8 oz. sugar-sweetened beverage per day was associated with a nearly 2.5 times greater risk for gastric cancer. The study, published in Gastro Hep Advances, found no link between intake of artificially sweetened beverages and incidence of gastric cancer.
Dietary factors \u2014 including increased consumption of salted fish, pickled vegetables and grilled or charcoaled meats along with lower intake of fruits and vegetables \u2014 are known contributors of gastric cancer, the fourth-leading cause of cancer deaths globally, according to study background. However, prior studies had not investigated the impact that beverages like soda, energy drinks and sweetened juice might have on gastric cancer incidence. \u201cWe already had strong evidence linking sugar-sweetened beverages to a higher risk for colorectal, breast and liver cancers,\u201d Andrew T. Chan, MD, MPH, chief of the Clinical and Translational Epidemiology Unit at Massachusetts General Hospital, director of epidemiology at Mass General Cancer Institute and Daniel K. Podolsky Professor of Medicine at Harvard Medical School, told Healio. \u201cGiven how almost 65% of U.S. adults consume at least one of these beverages a day, it seemed important to ask whether that same relationship might extend to stomach cancer.\u201d Chan and colleagues included artificially sweetened beverages in their analysis, because aspartame \u2014 a common artificial sweetener \u2014 is internationally recognized as a potential carcinogen, they wrote. The researchers collected data from the Nurses\u2019 Health Study and Health Professionals Follow-up Study, ongoing U.S.-based prospective cohorts that enrolled female registered nurses in 1976 and male healthcare professionals in 1986, respectively. Beverage intake was assessed via food frequency questionnaires administered every 4 years. Data from the 1986 questionnaire served as baseline, and analysis \u2014 adjusted for confounders such as red and processed meat consumption, BMI and other known risk factors \u2014 continued through January 2022. The researchers defined sugar-sweetened beverages as carbonated drinks, punch, lemonade and sports drinks, and artificially sweetened drinks as low-calorie carbonated beverages. Among 112,284 individuals (60.8% women) included in final analysis, 278 participants developed gastric cancer in 3,204,001 person-years of follow-up. Compared with those who never drank sugar-sweetened beverages, researchers observed significantly higher risk for gastric cancer among individuals who consumed at least one 8 oz. serving of a sugary drink daily (HR = 2.45; 95% CI, 1.49-4.04). \u201cThe association between sugary beverages and stomach cancer held up even when accounting for overweight and obesity, which is an independent risk factor for cancer,\u201d Chan said. By sex, incidence of gastric cancer also was significantly higher among women (HR = 3.04; 95% CI, 1.46-6.33) and men (HR = 1.99; 95% CI, 1-3.93) who consumed more than 8 ounces daily compared with never-users. \u201cIf this association holds up in future research, it means there may be a meaningful, actionable way for people to lower their risk for a cancer that is often diagnosed late and difficult to treat,\u201d Chan said. \u201cIt\u2019s also a reminder that diet\u2019s influence on cancer risk isn\u2019t limited to the cancers we usually think of, like colorectal cancer.\u201d Age- and multivariable-adjusted analysis showed no link between artificially sweetened beverage intake and gastric cancer incidence. Chan and colleagues acknowledged study limitations, including lack of data on Helicobacter pylori infection status and family history of gastric cancer. The cohorts also were predominantly composed of white individuals aged 30 to 75 years when enrolled, and results may not be generalizable to non-white or younger individuals. Additional research is needed to validate these findings and explore underlying mechanisms that may link sugar-sweetened beverage consumption to gastric cancer, the researchers wrote. \u201cWe don\u2019t yet know the precise mechanism, but several biological pathways have been proposed for how sugary drinks might contribute to cancer risk generally, including its effect on weight gain, insulin resistance and changes to the gut microbiome,\u201d Chan told Healio. For more information: Andrew T. Chan, MD, MPH, can be reached at gastroenterology@healio.com. Published by: Ask a clinical question and tap into Healio AI’s knowledge base.
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