What We Offer: A Full Spectrum of Aesthetic Services in Scottsdale Between Stephanie and Rhian, our aesthetic team covers the full range of treatments that today’s most discerning clients are looking for. Here’s what you can expect at NHLMA: Botox and Neurotoxins Our approach to Botox is one we’re proud of. We don’t believe in the frozen look. Every treatment starts with a full assessment of your facial movement and expression lines, and injections are placed precisely to relax rather than paralyze. The result is smooth, refreshed, and unmistakably you. Treatments take 15 to 30 minutes with no downtime, and results typically last three to four months. Dermal Fillers: Juvederm, Sculptra, and More From restoring cheek volume to defining the lips to subtle facial contouring, our nurses work with the world’s leading hyaluronic acid fillers and biostimulators — including Juvederm, Voluma, Volux, Kysse, SkinVive, and Sculptra. Every plan is custom-designed around your facial anatomy and your goals. We are widely recognized as one of Scottsdale’s leading destinations for natural lip filler and facial rejuvenation. Medical-Grade Facials Our medical-grade facials in Scottsdale go well beyond what you’d experience at a traditional spa. Each one is fully customized and may incorporate dermaplaning, facial cupping, lymphatic drainage, and acne-targeted treatments using the highest-grade clinical products available. We also offer oncology-approved facials for clients going through treatment who still want to prioritize skin health safely. Medical Microneedling, RF Microneedling and Laser Skin Resurfacing For clients looking to address texture, tone, fine lines, or acne scarring at a deeper level, we offer radiofrequency microneedling and laser skin resurfacing, treatments that stimulate collagen and produce results that build over time. Hydrafacial The Hydrafacial in Scottsdale remains one of the most universally loved treatments we offer. It deeply cleanses, exfoliates, and infuses the skin with targeted serums in a single session with zero downtime, making it a great standalone treatment or complement to other services. Source link

I have updated this post several times since first publishing it in 2018 as new companies come and go. Most of the companies in this list make other products in addition to those that just tackle hair loss. I focus on companies that have developed unique reputable products to regrow your hair. Some of these products are currently in clinical trials. Note that several well known companies such as Pelage Pharmaceuticals (US) and OrganTech (Japan) are privately held (so not publicly traded as yet). I do not cover the numerous companies that make products such as: laser hair growth devices; hairpieces; hair systems; shampoos; hair vitamins; and hair loss concealers. I do not cover telehealth companies that specialize in compounding and selling their own hair growth prescription products. You can find a list of some of the largest ones at the top of my post on topical finasteride. I also omit all major generic hair loss drug manufacturers. I do not include companies that make hair transplant related equipment or any other tools (e.g., PRP centrifuges, scalp drug delivery systems, microneedling devices, hair growth measurement and imaging system and so on). I have skipped the numerous companies working on alopecia areata (AA) related treatments. Around 95 percent of hair loss patients suffer from androgenetic alopecia (AGA). I have not covered the numerous companies in South Korea for the time being. Hair Loss Company Stock Prices Absci (US): ABSI — This company has been all the rage in 2026. Check out my regularly updated post on Absci and its ABS-201 AI-developed hair loss product that is currently in Phase 1 clinical trials. Allergan (Ireland): AGN — Working on a number of hair loss products such as Bimatoprost and Setipiprant. Hair loss segment accounts for a small portion of overall sales. Allergan has also invested in several hair loss companies in the recent past. Coegin Pharma (Ireland): COEGIN — Traded on the Nordic Growth Market for small and medium-sized enterprises. After purchasing Follicum (Sweden) in 2022, this company is developing the latter’s FOL-005 product as a cosmeceutical. Cosmo Pharmaceuticals (Ireland): COPN — Its Breezula androgen receptor targeting product is causing some excitement and will likely get FDA approval before the end of 2027. The company’s closely related acne fighting topical product Winlevi was released in the US in 2021 and has been a big success. Johnson & Johnson (US): JNJ — Although the company makes the original brand name FDA-approved hair loss blockbuster drug Rogaine (Minoxidil), it accounts for a very small portion of overall sales. Kintor Pharmaceutical (China): KNTPF — Currently in Phase 3 clinical trials, Kintor’s KX-826 product has a high chance of getting approved in China by the end of 2027. It targets the androgen receptor, just like Cosmo’s Breezula, which I discussed earlier. L’Oreal (France): OR:PA — World renowned cosmetics leader headquartered in France. In addition to investing in other hair loss companies, L’Oreal is working on 3D printed hair and grey hair reversal treatments. Merck (US): MRK — Although the company makes the original brand name hair loss FDA-approved blockbuster drug Propecia (Finasteride), it accounts for a very small portion of overall sales. Shiseido (Japan): (SSDOY) — A Japanese cosmetics behemoth that is especially significant in Asia. Basic adenosine based adenovital shampoos and other related hair growth products represent a significant portion of their overall sales. In 2024, Shiseido released its much anticipated DSC cell hair multiplication procedure in Japan. Veradermics (US): (MANE) — They raised a massive $150 million in financing in 2025 for their extended-release oral minoxidil tablet. Check out my post on Veradermics for the latest updates. Disclaimer: I am not a financial advisor or finance professional. As of the time of publishing this post, I do not own shares in any of the above companies. Source link

The Question That Changes Everything Before choosing between a transplant and non-surgical treatment, the most important question to ask is this: is your hair loss stable, or is it still progressing? If you’re still actively losing hair, a transplant won’t stop that process. The transplanted follicles may thrive, but the surrounding hair continues to thin, and you can end up in a worse position than if you’d addressed the underlying cause first. At NHLMA, we always recommend stabilizing hair loss before pursuing any surgical intervention. Not because we want to delay your results, but because doing things in the right order is what produces results that actually last. Non-surgical treatment is typically the right first move if: Your hair loss is still progressing or you haven’t yet addressed the root cause You’re in the early to moderate stages of thinning and have viable follicles to work with You’re not ready for surgery emotionally, financially, or practically You want to see how much regrowth is possible before making a permanent decision A transplant conversation makes more sense once your hair loss has been stabilized, your scalp health is optimized, and you’ve exhausted what’s possible without surgery. At that point, if there are areas that still need filling in, surgery becomes a much smarter investment, and you’ll need far fewer grafts than you would have otherwise. When Both Makes Sense Transplant and non-surgical treatment aren’t competing choices. For many people, the best outcome comes from doing both, using non-surgical therapies to stabilize loss and build a healthy scalp environment, and then using surgery to address any remaining structural concerns. We work with a trusted network of top transplant physicians across the country and provide referrals when surgery is genuinely the right next step. Our goal is never to talk you out of a transplant if that’s what’s right for you. It’s to make sure that if you do go that route, you go in prepared — with a scalp that’s ready, loss that’s stable, and a plan for protecting the results long-term. Why National and Scottsdale Patients Choose NHLMA We’re a hair specialty clinic, not a general med spa adds hair services. Every client receives a thorough evaluation before any treatment is recommended, and we work with each person based on their specific hair loss pattern, health history, and goals. We proudly serve clients throughout Scottsdale, North Scottsdale, Paradise Valley, Phoenix, Tempe, Chandler, and the broader East Valley, with virtual consultations available for those outside the area. Source link

Who Are They For? Both medications are primarily used for androgenetic alopecia, the most common type of hair loss driven by genetics and hormones. This includes male pattern hair loss and, in some cases, female pattern hair loss. Minoxidil is approved for both men and women. Topical minoxidil is available over the counter, while oral minoxidil requires a prescription. Finasteride is primarily prescribed for men. It is used off-label in some post-menopausal women with female pattern hair loss, but it is not appropriate for women who are pregnant or may become pregnant due to risks associated with fetal development. Side Effects: What to Know Minoxidil side effects are generally mild and may include: A temporary increase in shedding in the first few weeks (this is actually a sign the treatment is working, not a sign to stop) Scalp dryness or irritation with topical forms In rare cases, unwanted facial hair growth with topical application With oral minoxidil: fluid retention, low blood pressure, or increased body hair in a small number of people Finasteride side effects are less common than many people fear, but they’re worth understanding: Sexual side effects such as decreased libido or erectile dysfunction are reported in a small percentage of men, typically under 4% Mood changes in rare cases Side effects typically resolve when the medication is stopped Many people are anxious about finasteride before starting it and find that their experience is nothing like what they feared. That said, having an honest conversation with your clinician before starting is always the right move. How Much Do They Cost? This is one of the most common questions we hear, and the good news is that both medications are relatively affordable. Generic oral minoxidil typically runs $20 to $50 per month. Generic finasteride is usually $10 to $30 per month. When prescribed through a hair loss clinic, pricing can vary depending on the protocol, but it’s often competitive with pharmacy pricing and comes with the added benefit of clinical oversight. At NHLMA, we offer oral prescriptions for both medications as part of a clinician-supervised hair restoration protocol, which means you’re getting the right dosage, the right guidance, and a team that’s monitoring your progress. Source link

Amazon is the go to place for most people when it comes to buying non-prescription hair loss products. On this page, I list some of the most popular hair growth products on Amazon based on number of reviews. Shampoos Nizoral Shampoo. Not surprisingly, some of the best hair loss shampoos and dandruff shampoos have a massive number of reviews. Nizoral anti-dandruff shampoo has 111,000 reviews, with an average rating of 4.6 out of 5 stars. It also has anti-androgenic effects. Pura D’Or has become a renowned brand name in the world of hair. Its anti-thinning biotin shampoo and conditioner set currently has 66,000 reviews, with an average rating of 4.3 out of 5 stars. Tea Tree Special shampoo has 62,000 reviews, with an average rating of 4.6 out of 5 stars. The evergreen Head & Shoulders Classic has 23,000 reviews, with an impressive average rating of 4.8 out of 5 stars. I covered Nioxin in the past. Its System 2 currently has 21,500 reviews, with an average rating of 4.6 out of 5 stars. Concealers I have not updated my best hair loss concealers post recently, but the usual suspects still remain bestsellers. Toppik has 72,000 reviews, with an average rating of 4.3 out of 5 stars. I had great results from using this concealer in the past. Boldify has 11,000 reviews, with an average rating of 4.3 out of 5 stars. Hair Vitamins Hair Vitamins with Amino Acids. Hair vitamins are an especially popular product on Amazon. Partly because of their relatively low cost. Do note that in most cases, vitamins, herbs and natural products will not lead to any kind of hair regrowth. Unless you are severely deficient in any specific vitamin or mineral. Nature’s Bounty Biotin has 121,000 reviews, with an average rating of 4.7 out of 5 stars. The rapid release softgels claims to benefit hair, nails and skin. Vitafusion multivitamin gummies has 93,000 reviews (across an old and new version), with an average rating of 4.6 out of 5 stars. It includes Vitamin B, Biotin, Vitamin D and Retinol among other ingredients. It claims to benefit hair, nails and skin. Sugarbear Hair Vitamins has 48,000 reviews, with an average rating of 4.3 out of 5 stars. They are in gummy form and vegan. They include Vitamin A, Biotin, Vitamin C, Choline, Vitamin D, Vitamin E, Vitamin B-6, Vitamin B-12, Folate, Iodine and Zinc. Other Hair Loss Products Below I list other very popular hair loss products on Amazon. Feel free to add comments if you find others with more customer reviews. I covered both Viviscal and Nutrafol in the past. They are among the most popular supplements on Amazon that are specifically developed for hair loss. Viviscal currently has 30,000 reviews, with an average rating of 4.3 out of 5 stars. Nutrafol has 18,500 reviews, with an average rating of 4.2 out of 5 stars. Men’s Rogaine foam has 29,000 reviews and a 3-month supply is currently being sold at a big discount of 25%. It has an average rating of 4.2 out of 5 stars. Interestingly, Women’s Rogaine has 18,600 reviews, a somewhat higher number than I would expect relative to the men’s product. Also make sure to check out all the products listed in my post on Redensyl, Capixyl, Procapil and Baicapil. Source link

Using artificial intelligence (AI) and machine learning (ML) for hair loss drug discovery. In the past, I briefly discussed the use of artificial intelligence (AI) and machine learning (ML) in drug discovery. Especially when it comes to the potential of rapidly testing new compounds to treat hair loss. Funding for drug discovery startups that use AI is now really taking off. Heavyweight companies such as Amazon, Anthropic, Google and Palantir increasingly focusing in this area. However, the AI drug boom is still in its early stages. Note that this post was originally written in November 2022, but needed an update due to a many new developments. Hair Loss Companies using AI to Develop new Drugs A number of hair loss companies are currently developing new drugs via the use of AI. I will update this section regularly. The most widely covered of these is Absci (US), an artificial intelligence drug and biologic creation company that is developing novel treatments via the use generative AI. Their most anticipated product is a prolactin receptor (PRLR) targeting injection based hair growth treatment called ABS-201. It is in Phase 1 clinical trials as of 2026. In 2026, a new start-up named RE:YOU claimed to have developed four new molecules to benefit hair growth using AI. A few years ago, there was much hype about a new AI drug discovery company named Insilico Medicine (Hong Kong). Among the conditions the company aimed to develop drugs for included hair loss. While they mentioned hair in a number of their past press releases, you no longer see it on their pipeline page. Update: Eli Lilly (US) and Insilico struck a $2.75 billion AI drug discovery deal in March 2026. And Takeda (Japan) and Insilico struck a $600 million AI drug discovery deal in July 2026. Another hair loss company making use of AI is South Korea’s Epibiotech. In October 2021, it signed an agreement with CN.AI in order to accelerate the discovery of new hair loss drug candidates. Also of interest, in December 2019, Iktos (France) and Almirall (Spain) signed an agreement in which Iktos’ AI modelling technology would be used to design novel optimized compounds for Almirall. The latter is a company that is entirely focused on skin and other dermatological conditions. They currently make the world’s only topical finasteride product that has undergone rigorous clinical trials. Using AI to Predict Hair Loss Compounds What made me first write this post was an interesting article titled: “Researchers use AI to predict compounds that could neutralize baldness.” The actual study from China is here and it was published on October 20, 2022. In the article, they mention that male pattern hair loss is caused by androgens, inflammation or an overabundance of reactive oxygen species. One potential treatment for the last mentioned is via the creation and utilization of “nanozymes” that mimic the superoxide dismutase (SOD) enzyme. SOD helps fight damaging oxygen free radicals. The scientists tested machine-learning models with 91 different transition-metal, phosphate and sulfate combinations. A highly efficient manganese thiophosphite (MnPS3) based SOD mimic was discovered using machine learning tools. These ML techniques predicted what cobination would have the most powerful SOD-like ability. The team subsequently prepared MnPS3 microneedle patches which they used to treat androgenic alopecia-affected mouse models. Microneedling allowed the MnPS3 to penetrate deep layers of the skin (where hair follicle stem cells reside) and remove the excess reactive oxygen species. Within 13 days, the animals regenerated thicker hair strands that more densely covered their previously bald backsides. Also check out how it is possible to speed up drug discovery with diffusion generative models (such as the DiffDock molecular docking model). Opensource Databases and Resources Although not exactly AI, I find the increasing number of online opensource resources, databases, repositories and collaborative research tools encouraging. Make sure to read my post on the publicly available DeepMind AlphaFold protein database. You can search for “hair” in there and get 2,200 results as of today. In addition to the general DeepMind/AlphaFold GitHub, we also have hair specific ones such as the BiernaskieLab GitHub. Also of interest are open source sites such as the Driskskell Lab’s skin regeneration and wound healing related datasets. More recently, Dr. Maksim Plikus and his team at UCI developed CellChat, which enables the better understanding of cell-to-cell communication and signaling. Other AI Applications in the Hair Loss World Note that artificial intelligence is also being used for other purposes beside drug discovery in the hair loss world. Among these include: New AI Solution to Diagnose Hair Loss Type via Scalp Biomarkers Cosmetics manufacturer Kolmar Korea (South Korea) has developed an artificial intelligence-based solution that can diagnose hair loss using scalp biomarkers. The technology can diagnose 16 different types of androgenic hair loss (nine male and seven female). A dermatologist collects samples of a patient’s scalp, places them on proprietary analytics equipment, and has the AI-powered tool screen scalp surface biomarkers. Kolmar Korea expects that its diagnostic tool will help hair loss patients and dermatologists choose optimized treatments. The company also plans to develop various cosmetics that target each of the 16 different types of androgen related hair loss. Source link

RE:YOU. AI-enabled new hair growth molecule discovery. In 2022, I wrote a post about the increasing use of artificial intelligence (AI) to discover new hair loss drugs. This phenomenon has really grabbed attention this week. First, we heard about Absci (US) raising $100 million for its generative AI-developed hair loss drug ABS-201 (after positive interim Phase 1 clinical trial findings). And now I discuss a brand new company called RE:YOU (US). RE:YOU: AI-Enabled Discovery of Small Molecules for Hair Follicle Rejuvenation Several days ago, a new US-based company named RE-YOU (or Re:You) was covered in BioSpace. They announced promising preclinical research in relation to the AI-enabled drug discovery of four novel molecules for hair growth. Each of these four molecules targets a distinct biological pathway involved in hair follicle growth and the scalp environment. All four molecules were evaluated in primary human cell systems and human hair follicle organoid models. Moreover, the scientists behind this discovery published a lengthy pre-print paper in bioRxiv on June 9, 2026. It is titled: “AI-enabled discovery of small molecules targeting complementary pathways for hair follicle rejuvenation.” RE:YOU has named the four molecules as follows: NV-623 and NV-624. Both support and “energize” dermal papilla cell viability and proliferation. Each molecule supposedly showed 30% greater hair growth in comparison to minoxidil. NV-273. Inhibits prolyl hydroxylase domain protein 2 (PHD2), activates hypoxia-inducible factor-1α (HIF-1α) and increases secretion of VEGF-A and lactate. All of this is supposed to benefit the scalp hair growth environment, circulation and regenerative signaling. Interestingly, the massively hyped Pelage Pharmaceuticals’ PP405 hair growth product works by boosting lactate production. NV-1065. A non-steroidal inhibitor of 5α-reductase, the enzyme responsible for converting testosterone into dihydrotestosterone (DHT). The later is the key cause of male pattern hair loss. The researchers claim that this molecule suppresses DHT to a similar extent as dutasteride. Amazing if true. RE:YOU classifies its portfolio of multi-pathway hair growth molecules under the brand name NOVOGRO™. Someone has written a very lengthy article on minoxidil vs Novogro that might be worth a read. I did not have the time or motivation to go through it as yet. Key quote from the BioSpace article: “Using a combination of machine learning, graph neural networks, structure-based virtual screening, and experimental validation, researchers screened more than 20 million compounds and identified four lead candidates with distinct mechanisms of action.” All of this sounds very interesting due to the involvement of AI-led drug discovery. Especially if the company can deliver something brand new to topically inhibit scalp DHT levels (without causing any of the potential side effects of oral dutasteride). But at the moment, I remain skeptical and would not be surprised if all we get is yet another new hair loss cosmeceutical product. If the pre-print article gets published in a reputable journal, I will get a bit more interested. At the bottom of RE:YOU’s home page, they say that: “A 150+ subject, 6-month, double-blinded, randomized controlled trial comparing NOVOGRO™ -powered serum (NV-273, NV-623, NV-624) with a minoxidil benchmark arm is currently underway.” They hope that an interim dataset will be available by the end of July 2026. To me, a comparison with finasteride or dutasteride would be more interesting. Note that this company and the study co-authors are in various ways affiliated with Integrated Biosciences and LK Innovations. Source link

Diabetes and Androgenetic Alopecia (AGA) Connection. In 2017, I wrote a post about how male pattern hair loss and hair graying were both correlated with significantly increased rates of heart disease. This is especially true if someone is balding or graying at an early age, and if they have crown (vertex) area hair loss. Both androgenetic alopecia (AGA) and heart disease also have a strong inflammatory component. Interestingly, hair loss drug Minoxidil likely has brain and heart health benefits due to its making stiff arteries and blood vessels more flexible. Thereby lowering blood pressure, albeit modestly if taking a low dose to fight hair loss. Early-Onset Androgenetic Alopecia Indicates Diabetes Risk In the July 2026 issue of the Journal of the American Academy of Dermatology, a new study from China concludes that: “Early-onset androgenetic alopecia may indicate diabetes mellitus (DM) risk in young and middle-aged adults.” A massive 12,000 participants were analyzed in the study. The AGA prevalence rate was 32.4% in males and 7.1% in females. Interestingly, while the analysis revealed a significantly higher rate of DM in AGA patients aged between 18-49 years, no such correlation was seen in patients aged over 50 years. I first heard about this study from dermatologist and hair loss expert Dr. Maryanne Makredes Senna’s recent video on Instagram. Some past studies have found a connection between AGA and higher rates of both insulin resistance and metabolic syndrome. And a 2019 US study found that Type 2 diabetes was associated with an increased risk of severe central scalp hair loss in African American women. All of these findings are not necessarily conclusive as yet. But if you are young and have crown hair loss, it is probably worth monitoring your cholesterol, blood pressure and glucose (sugar) levels regularly. Also make sure to read my past post on the possible connection between diet, lifestyle and hair loss per one reader’s impressive 60-page research. If only far more homeless people and alcoholics were balding, a lot of people would take this connection more seriously! Humans tend to believe their eyes and real life experiences more than study findings. Unfortunately, it has probably never been studied as to whether people who go bald at a younger age end up being less likely to take care of their overall health. i.e., they exercise less, eat more fast food, drink more and suffer from higher rates of depression and loneliness. Anecdotal online stories on hair loss forums suggest this as a strong possibility. Source link

Nutritional Deficiencies Hair follicles are among the most metabolically active structures in the body, which means they are highly sensitive to nutritional gaps. The most common deficiencies linked to female hair loss are iron and ferritin, vitamin D, zinc, and B vitamins. Ferritin is particularly important and frequently overlooked. Standard iron panels often come back in the normal range while ferritin, the protein that stores iron, remains low enough to impair hair growth. A functional workup that specifically includes ferritin is essential for any woman experiencing unexplained shedding. Crash dieting and rapid weight loss are common triggers for telogen effluvium because they create sudden nutritional stress for the follicle. If you have recently changed your diet significantly or are on a GLP-1 medication for weight management, hair shedding can be a side effect worth discussing with your provider. Scalp Conditions and Inflammation Chronic scalp inflammation, whether from seborrheic dermatitis, psoriasis, or other conditions, can disrupt the follicle environment and contribute to hair loss over time. An unhealthy scalp is a less hospitable environment for hair growth, which is why scalp health is an important piece of any hair restoration approach. Medications Certain medications can contribute to hair loss in women, including some antihistamines, blood thinners, antidepressants, and hormonal contraceptives. If you started a new medication and noticed shedding a few months later, that timing is worth flagging with your provider.  We also offer a genetic test for hair loss that is a game-changer for hair loss treatments, providing a personalized treatment plan that uses your unique DNA to eliminate the frustration of trial and error. By analyzing your genetic data, this test precisely identifies the most effective medications and compounds for your biological needs, helping your provider choose the optimal treatment from day one. This scientific approach ensures you avoid ineffective solutions and potential side effects, allowing you to accelerate results and achieve significant, successful hair restoration much faster than with traditional, generic methods. Source link

If you have tried every eye cream on the market and still feel like your under-eye area is aging faster than the rest of your face, you are not alone, and you are not imagining it. The skin under the eyes is the thinnest on the entire face. It loses collagen and volume faster than anywhere else, and once that hollowness or darkness sets in, topical products can only do so much. PRF under eye treatment is one of the most effective non-surgical options available for addressing this, and it is one of the services we offer at our Scottsdale location. Here is the honest breakdown of what it does and who it is actually right for. What Is PRF? PRF stands for platelet-rich fibrin. It is a next-generation evolution of PRP (platelet-rich plasma) that uses your own blood to create a concentrated healing solution that is then injected into the treatment area. Here is how it differs from PRP. Both treatments involve drawing a small amount of your blood and spinning it in a centrifuge to separate the components. PRP isolates the plasma layer and its growth factors. PRF takes this further, it is spun at a slower speed and without anticoagulants, which produces a fibrin matrix that traps a higher concentration of platelets, growth factors, and white blood cells. The result is a more potent and longer-lasting regenerative effect at the injection site. In practical terms, PRF releases its growth factors slowly over time rather than all at once, which means the regenerative process continues in the tissue for days and weeks after the treatment rather than just in the immediate window post-injection. What PRF Does for the Under-Eye Area The under-eye area ages the way it does for a few distinct reasons: loss of collagen and elastin thinning of the skin reduction in fat volume beneath the surface and in some cases, visible blood vessels that create the appearance of darkness. PRF addresses several of these simultaneously. The concentrated growth factors stimulate collagen production in the treated area, which gradually thickens and firms the skin over the following weeks. The fibrin matrix also improves local circulation and tissue quality, which can reduce the translucency that makes blood vessels visible underneath the skin. Because PRF uses your own biological material, it also integrates into the tissue rather than sitting on top of it. This makes it particularly well-suited for the delicate under-eye area, where foreign fillers can sometimes create the bluish discoloration known as the Tyndall effect. Results build gradually rather than appearing immediately, which is one of the things that makes PRF look natural. Most patients notice meaningful improvement in skin quality, thickness, and the appearance of darkness and hollowness over a period of four to eight weeks following treatment. Source link